The results showed no myelotoxic effect or autoimmune effect on peripheralblood cells and no pathological effect on the liver, kidney, and spleen tissues. Biochemicalparameters of blood and histological parameters of the liver, kidneys, and spleen of the rats were analyzed after 120 days ofconsumption of the aqueous extract of ALBO-MPSA. The current study aims to evaluatea subchronic systemic toxicity of ALBO-MPSA on the rat animal model, as a continuation of the previous studies. Necrosis was not observed in any case, neither the presence of Gram-positive bacteria in the pulp.Ĭonclusion Histological analysis indicated favorable therapeutic effects of new nanostructural materials based on calcium silicate systems and hydroxyapatite for direct pulp capping in teeth of Vietnamese pigs.Īs an alternative to MTA, a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has beensynthesized, and its biocompatibility has been studied in manyin vitroandin vivostudies. Neoangiogenesis and many odontoblast like cells responsible for dentin bridge formation were detected. Inflammation of the pulp was mild to moderate in all groups. Results Dentin bridge was observed in all teeth (experimental and control groups). Pulp, pulp tissue reorganization and the presence of bacteria. After sacrificing the animals, histological preparations were done to analyze the presence of dentin bridge, inflammatory reaction of the All cavities were restored with glass ionomer cement (GC Fuji VIII, GC Corporation, Tokyo, Japan).
In the control group, exposed pulp was covered with Pro Root MTA® (Dentsply Tulsa Dental, Johnson City, TN, USA) (10 teeth). Of calcium silicate systems and hydroxyapatite (HA-CS) (10 teeth). In the second experimental group, the perforation was covered with compound In the first experimental group (10 teeth) the perforation was covered with new nanostructural material based on calcium silicate systems (CS). On buccal surfaces of incisors, canines and first premolars, class V cavities were prepared with a small round bur and pulp horn was exposed.
Material and Methods The study was conducted on 30 teeth of two Vietnamese pigs (Sus scrofa verus).
The aim of this study was to investigate the effects of new nanostructural materials based on calcium silicate systems and hydroxyapatite on exposed dental pulp in Vietnamese pigs. Introduction Direct pulp capping is an important therapeutic method that has goal to provide formation of dentin bridge and healing process of the pulp.
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